NSC 42834

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Chemical Structure| 195371-52-9 同义名 : JAK2 Inhibitor V; Z3; Z3. JAK2 Inhibitor V.; Janus-Associated Kinase Inhibitor V
CAS号 : 195371-52-9
货号 : A771055
分子式 : C23H24N2O
纯度 : 99%+
分子量 : 344.45
MDL号 : MFCD00023550
存储条件：

Pure form Inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 NSC 42834, a specific inhibitor of Jak2, inhibits Jak2-V617F and Jak2-WT autophosphorylation in a dose-dependent manner but was not cytotoxic to cells at concentrations that inhibited kinase activity.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.90mL

0.58mL

0.29mL

14.52mL

2.90mL

1.45mL

29.03mL

5.81mL

2.90mL
参考文献

[1]Jacqueline S, Peter P. S,. Jak2 inhibitors: Rationale and role as therapeutic agents in hematologic malignancies. March 2009, Volume 11, Issue 2, pp 117–124

[2]Jacqueline S, Andrew M, et al. AACR Journals: Z3, a novel Jak2 tyrosine kinase small-molecule inhibitor that suppresses Jak2-mediated pathologic cell growth. August 2008