同义名 :	莪术醇 ;(+)-Curcumenol
	CAS号 :	19431-84-6
	货号 :	A767094
	分子式 :	C15H22O2
	纯度 :	99%
	分子量 :	234.33
	MDL号 :	MFCD01729508
	存储条件：	Pure form Sealed in dry, 2-8°C In solvent -20°C:3-6个月-80°C:12个月
	溶解度 :	-
	动物实验配方：

生物活性

描述

Curcumenol is a potent CYP3A4 inhibitor with an IC50 of 12.6 μM, which is one of constituents in the plants of medicinally important genus of Curcuma zedoaria, with neuroprotection, anti-inflammatory, anti-tumor and hepatoprotective activities[2]. Curcumenol also remarkably enhanced myogenic differentiation and mitochondrial function[3]. Curcumenol diminishes the proinflammatory mediators and the expression of the regulatory genes in LPS-stimulated BV-2 by inhibiting Akt-dependent NF-κB activation and downregulation of Akt and p38 MAPKs signaling[4]. Curcumenol mitigated inflammation in ATDC5 chondrocytes and primary mice chondrocytes, and also ameliorated OA (osteoarthritis) in a DMM(destabilization of medial meniscus)‑induced mouse model[5].

实验方案
	1mg	5mg	10mg
1 mM 5 mM 10 mM	4.27mL 0.85mL 0.43mL	21.34mL 4.27mL 2.13mL	42.67mL 8.54mL 4.27mL

参考文献

[2]Sun DX, Fang ZZ, Zhang YY, Cao YF, Yang L, Yin J. Inhibitory effects of curcumenol on human liver cytochrome P450 enzymes. Phytother Res. 2010 Aug;24(8):1213-6 [3]Zhang LS , Shen SN , Gao YL , Shi SY , Zhou CX , Mo JX , Xu YK , Lin LG , Gan LS . Tautomerism and bioactivities of curcumenol, a common sesquiterpenoid widely existing in edible plants. Food Funct. 2019 Mar 20;10(3):1288-1294 [4]Lo JY, Kamarudin MN, Hamdi OA, Awang K, Kadir HA. Curcumenol isolated from Curcuma zedoaria suppresses Akt-mediated NF-κB activation and p38 MAPK signaling pathway in LPS-stimulated BV-2 microglial cells. Food Funct. 2015 Nov;6(11):3550-9 [5]Yang X, Zhou Y, Chen Z, Chen C, Han C, Li X, Tian H, Cheng X, Zhang K, Zhou T, Zhao J. Curcumenol mitigates chondrocyte inflammation by inhibiting the NF‑κB and MAPK pathways, and ameliorates DMM‑induced OA in mice. Int J Mol Med. 2021 Oct;48(4):192