Pyr10

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Chemical Structure| 1315323-00-2 同义名 : -
CAS号 : 1315323-00-2
货号 : A757208
分子式 : C18H13F6N3O2S
纯度 : 99%+
分子量 : 449.37
MDL号 : MFCD28411625
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：

IP 2% DMSO+water 0.1 mg/mL clear

PO 0.5% CMC-Na 44 mg/mL suspension

生物活性
描述 Pyr10, a pyrazole derivative, is a selective inhibitor of the Transient Receptor Potential Cation Channel, Subfamily C, Member 3 (TRPC3). It inhibits calcium influx in TRPC3-transfected HEK293 cells stimulated by carbachol with an IC50 of 0.72 μM, while its IC50 for inhibiting store-operated calcium entry in BRL-2H3 cells is 13.08 μM. This specificity allows Pyr10 to differentiate between receptor-operated TRPC3 channels and native STIM1/Orai1 channels[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.23mL

0.45mL

0.22mL

11.13mL

2.23mL

1.11mL

22.25mL

4.45mL

2.23mL
参考文献

[1]Schleifer H, et al. Novel pyrazole compounds for pharmacological discrimination between receptor-operated and store-operated Ca(2+) entry pathways. Br J Pharmacol. 2012 Dec;167(8):1712-1722.

[2]Saliba Y, et al. Transient Receptor Potential Canonical 3 and Nuclear Factor of Activated T Cells C3 Signaling Pathway Critically Regulates Myocardial Fibrosis. Antioxid Redox Signal. 2019 Jun 1;30(16):1851-1879.