同义名 :	Rubimaillin
	CAS号 :	55481-88-4
	货号 :	A753804
	分子式 :	C17H16O4
	纯度 :	99%+
	分子量 :	284.31
	MDL号 :	MFCD02752331
	存储条件：	Pure form Sealed in dry, 2-8°C In solvent -20°C:3-6个月-80°C:12个月
	溶解度 :	-
	动物实验配方：

生物活性

描述

Mollugin is a major bioactive component isolated from Rubia cordifolia L. Mollugin attenuated the LPS-induced expression of nitric oxide (NO), inducible nitric oxide synthase (iNOS), interleukin (IL)-1β and IL-6 but augmented the expression of tumor necrosis factor (TNF)-α[3]. Mollugin induces cell death in a dose-dependent manner in primary and metastatic OSCCs (human oral squamous cell carcinoma cells). Mollugin-induced cell death involved apoptosis, characterized by the appearance of nuclear shrinkage, flow cytometric analysis of sub-G1 phase arrest, and annexin V-FITC and propidium iodide staining[4]. Mollugin significantly inhibited the expression of an NF-κB reporter gene induced by tumor necrosis factor (TNF)-α in a dose-dependent manner. Moreover, mollugin inhibited TNF-α-induced phosphorylation and nuclear translocation of p65, phosphorylation and degradation of inhibitor of κB (IκBα), and IκB kinase (IKK) phosphorylation[5].

实验方案
	1mg	5mg	10mg
1 mM 5 mM 10 mM	3.52mL 0.70mL 0.35mL	17.59mL 3.52mL 1.76mL	35.17mL 7.03mL 3.52mL

参考文献

[1]Baek JM, Kim JY, et al. Mollugin from Rubea cordifolia suppresses receptor activator of nuclear factor-κB ligand-induced osteoclastogenesis and bone resorbing activity in vitro and prevents lipopolysaccharide-induced bone loss in vivo. Phytomedicine. 2015 Jan 15;22(1):27-35. [2]Zhang L, Wang H, et al. Mollugin induces tumor cell apoptosis and autophagy via the PI3K/AKT/mTOR/p70S6K and ERK signaling pathways. Biochem Biophys Res Commun. 2014 Jul 18;450(1):247-54. [3]Zhu ZG, Jin H, Yu PJ, Tian YX, Zhang JJ, Wu SG. Mollugin inhibits the inflammatory response in lipopolysaccharide-stimulated RAW264.7 macrophages by blocking the Janus kinase-signal transducers and activators of transcription signaling pathway. Biol Pharm Bull. 2013;36(3):399-406 [4]Lee YM, Auh QS, Lee DW, Kim JY, Jung HJ, Lee SH, Kim EC. Involvement of Nrf2-mediated upregulation of heme oxygenase-1 in mollugin-induced growth inhibition and apoptosis in human oral cancer cells. Biomed Res Int. 2013;2013:210604 [5]Wang Z, Li MY, Mi C, Wang KS, Ma J, Jin X. Mollugin Has an Anti-Cancer Therapeutic Effect by Inhibiting TNF-α-Induced NF-κB Activation. Int J Mol Sci. 2017 Jul 26;18(8):1619