L-006235
产品说明书
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同义名 : | L-235 |
| CAS号 : | 294623-49-7 | |
| 货号 : | A753567 | |
| 分子式 : | C24H30N6O2S | |
| 纯度 : | 99%+ | |
| 分子量 : | 466.6 | |
| MDL号 : | MFCD18086856 | |
| 存储条件： |
Pure form Sealed in dry, 2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | L-006235, also known as L-235, is a potent, selective, reversible and orally active cathepsin K inhibitor with an IC50 of 5 nM in bone resorption assay.Compared to cathepsin B, cathepsin L and cathepsin S (Ki=1, 6 and 47 μM, respectively), the effects of L-006235 on cathepsin K (Ki=1, 6 and 47 μM) were significant. Compared with cathepsin B, chepsin L and cathepsin S (Ki = 1, 6 and 47 μM, respectively), L-006235 is more selective for cathepsin K (Ki = 0.2 nM), and L-006235 reduces collagen degradation and prevents bone loss[1][2].In a rabbit bone resorption assay, L-006235 inhibited bone resorption with an IC50 of 5 nM[1] . | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.14mL 0.43mL 0.21mL |
10.72mL 2.14mL 1.07mL |
21.43mL 4.29mL 2.14mL |
