CJ-42794

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Chemical Structure| 847728-01-2 同义名 : CJ-042794; RQ-00015986; RQ-00015986, RQ-15986.
CAS号 : 847728-01-2
货号 : A747666
分子式 : C22H17ClFNO4
纯度 : 99%+
分子量 : 413.83
MDL号 : MFCD13184815
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 CJ-42794 is a selective prostaglandin E receptor subtype 4 (EP4) antagonist, inhibits [3H]-PGE2 binding to the human EP4 receptor with a mean pKi of 8.5, a binding affinity that was at least 200-fold selective for the human EP4 receptor than other human EP receptor subtypes (EP1, EP2, and EP3).
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.42mL

0.48mL

0.24mL

12.08mL

2.42mL

1.21mL

24.16mL

4.83mL

2.42mL
参考文献

[1]Murase A, Taniguchi Y, et al. In vitro pharmacological characterization of CJ-042794, a novel, potent, and selective prostaglandin EP(4) receptor antagonist. Life Sci. 2008 Jan 16;82(3-4):226-32.

[2]Hatazawa R, Tanaka A, et al. Cyclooxygenase-2/prostaglandin E2 accelerates the healing of gastric ulcers via EP4 receptors. Am J Physiol Gastrointest Liver Physiol. 2007 Oct;293(4):G788-97.