Tilmicosin
产品说明书
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同义名 : | LY-177370; EL-870 |
| CAS号 : | 108050-54-0 | |
| 货号 : | A734205 | |
| 分子式 : | C46H80N2O13 | |
| 纯度 : | 98% | |
| 分子量 : | 869.13 | |
| MDL号 : | MFCD00864842 | |
| 存储条件： |
Pure form Inert atmosphere, store in freezer, under -20°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Tilmicosin is a widely used antibiotic in veterinary applications. Its antimicrobial activity is ranged from Gram-positive and some Gram-negative bacteria towards activities against Mycoplasma and Chlamydia[3]. The MIC90 of tilmicosin against Haemophilus parasuis, Actinbacillus pleuropneumoniae, and Pasteurella multocida were all 8 μg/ml. The relative bioavailability of tilmicosin enteric granules to premix was 114.97 ± 7.19%, according to the AUC0-t values[4]. Tilmicosin is used to treat intramammary infections against Staphylococcus aureus and has clinical anti-inflammatory effects. Tilmicosin decreases intracellular infection and had a protective effect on MAC-T (immortalized mammary epithelial cells) reducing apoptosis after infection by 80%. Furthermore, tilmicosin reduced reactive oxygen species (ROS), IL-1β, IL-6, and TNF-αproduction. The anti-inflammatory effect of tilmicosin helped to preserve casein synthesis in mammary epithelial cells[5]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
1.15mL 0.23mL 0.12mL |
5.75mL 1.15mL 0.58mL |
11.51mL 2.30mL 1.15mL |
| 参考文献 |
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