Fesoterodine fumarate

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Chemical Structure| 286930-03-8 同义名 : SPM 907; SMP 8272; Fesoterodine (fumarate)
CAS号 : 286930-03-8
货号 : A733103
分子式 : C30H41NO7
纯度 : 95%
分子量 : 527.65
MDL号 : MFCD12756004
存储条件：

Pure form Inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 (R)-Fesoterodine fumarate is an antimuscarinic agent and is rapidly de-esterified to its active metabolite 5-hydroxymethyl tolterodine that is a muscarinic receptor antagonist.
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT01302054 Urinary Bladder, Overactive Phase 4 Completed - -
NCT01557244 Urinary Bladder, Neurogenic Phase 3 Recruiting November 13, 2019 -
NCT01302067 Overactive Bladder Phase 4 Completed - -
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.90mL

0.38mL

0.19mL

9.48mL

1.90mL

0.95mL

18.95mL

3.79mL

1.90mL
参考文献

[1]Vella M, Cardozo L. Review of fesoterodine. Expert Opin Drug Saf. 2011 Sep;10(5):805-8. doi: 10.1517/14740338.2011.591377. Epub 2011 Jun 4.

[2]Malhotra B, Gandelman K, et al. The design and development of fesoterodine as a prodrug of 5-hydroxymethyl tolterodine (5-HMT), the active metabolite of tolterodine. Curr Med Chem. 2009;16(33):4481-9.