AMG131
产品说明书
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同义名 : | INT131 |
| CAS号 : | 315224-26-1 | |
| 货号 : | A730462 | |
| 分子式 : | C21H12Cl4N2O3S | |
| 纯度 : | 95% | |
| 分子量 : | 514.21 | |
| MDL号 : | MFCD13152369 | |
| 存储条件： |
Pure form Sealed in dry, 2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | AMG-131 is a hypoglycemic agent. It is a potent PPARγ partial agonist that displays robust glucose-lowering activity in rodent models of diabetes while exhibiting a reduced side-effects profile compared to marketed TZDs. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT00952445 | Diabetes Mellitus, Type II | Phase 2 | Completed | - | United States, California ... 展开 >> Whittier Diabetes Institute La Jolla, California, United States Charles R. Drew University Los Angeles, California, United States National Research Institute Los Angeles, California, United States Lovelace Research Institute Santa Ana, California, United States United States, Florida University of Miami Miami, Florida, United States United States, Indiana GFI Research Center Evansville, Indiana, United States United States, Massachusetts Joslin Diabetes Center Boston, Massachusetts, United States United States, Minnesota Radiant Research Edina, Minnesota, United States United States, Missouri Radiant Research St. Louis, Missouri, United States St Louis Center for Clinical Research St. Louis, Missouri, United States United States, New York Kaleida Health Diabetes Center Buffalo, New York, United States Rochester Clinical Research Rochester, New York, United States United States, North Carolina Duke University Medical Center Durham, North Carolina, United States United States, Oregon Radiant Research Portland, Oregon, United States United States, South Carolina Radiant Research Anderson, South Carolina, United States United States, Texas Baylor University Endocrine Center Dallas, Texas, United States Dallas Diabetes and Endocrine Research Center Dallas, Texas, United States Endocrine Associates of Dallas Dallas, Texas, United States Diabetes and Grandular Disease Clinic and Reseach Center San Antonio, Texas, United States United States, Utah Endocrine Research Specialists Ogden, Utah, United States United States, Virginia Salem VA Medical Center Salem, Virginia, United States 收起 << |
| NCT02638038 | Multiple Sclerosis, Relapsing ... 展开 >>Remitting 收起 << | Phase 2 | Completed | - | - |
| NCT00631007 | - | Completed | - | - | |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
1.94mL 0.39mL 0.19mL |
9.72mL 1.94mL 0.97mL |
19.45mL 3.89mL 1.94mL |
| 参考文献 |
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