同义名 :	-
	CAS号 :	618913-30-7
	货号 :	A724557
	分子式 :	C10H12N4O2S
	纯度 :	99%+
	分子量 :	252.29
	MDL号 :	MFCD31619279
	存储条件：	Pure form Sealed in dry, 2-8°C In solvent -20°C:3-6个月-80°C:12个月
	溶解度 :	-
	动物实验配方：

生物活性

描述

Myeloperoxidase (MPO) is a peroxidase enzyme that acts as a key regulator of oxidative stress-mediated apoptosis in cells. AZD5904 is an irreversible MPO inhibitor with similar potency in human (IC50 = 140 nM), rats, and mice. In isolated human neutrophils, AZD5904 at a concentration of 1 μM inhibited PMA-stimulated HOCl by over 90%. Rats with a plasma content of AZD5904 at around 5 μM showed decreased in vivo formation of glutathione sulphonamide from in situ zymosan activated peritoneum neutrophils. AZD5904 has low CNS penetration[1].

实验方案
	1mg	5mg	10mg
1 mM 5 mM 10 mM	3.96mL 0.79mL 0.40mL	19.82mL 3.96mL 1.98mL	39.64mL 7.93mL 3.96mL

参考文献
[1]AZD5904