PF-06726304
产品说明书
 |
同义名 : | PF-6726304 |
| CAS号 : | 1616287-82-1 | |
| 货号 : | A724309 | |
| 分子式 : | C22H21Cl2N3O3 | |
| 纯度 : | 99%+ | |
| 分子量 : | 446.33 | |
| MDL号 : | MFCD31563584 | |
| 存储条件： |
Pure form Keep in dark place, sealed in dry, store in freezer, under -20°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | PF-06726304 is a potent and selective EZH2 inhibitor. PF-06726304 inhibited EZH2-WT and EZH2-Y641N mutant with Ki values of 0.7 and 3.0 nM, respectively. PF-06726304 inhibited H3K27me3 in Karpas-422 with an IC50 value of 15 nM. PF-06726304 has strong anti-tumour growth activity[1]. PF-06726304 inhibited the proliferation of Karpas-422 cells carrying wild-type EZH2 with an IC50 of 25 nM[1] . | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
2.24mL 0.45mL 0.22mL |
11.20mL 2.24mL 1.12mL |
22.40mL 4.48mL 2.24mL |
