ML349
产品说明书
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同义名 : | - |
| CAS号 : | 890819-86-0 | |
| 货号 : | A723701 | |
| 分子式 : | C23H22N2O4S2 | |
| 纯度 : | 98% | |
| 分子量 : | 454.56 | |
| MDL号 : | MFCD14808090 | |
| 存储条件： |
Pure form Sealed in dry, 2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | ML349, identified as a strong and selective inhibitor for APT2 and LYPLA2, has a Ki of 120 nM and an IC50 of 144 nM. It exhibits high selectivity for LYPLA2 over LYPLA1, with Ki values for APT-1 and APT-2 being >10000 nM and 120±20 nM, respectively. Furthermore, ML349 inhibits both LYPLA1 and LYPLA2 with IC50s of >3000 nM and 144 nM, respectively[1][2]. ML348 and ML349 are not associated with a reduction in cell viability; however, they induce a minor activation of the AKT pathway in cells with NRAS mutations[3]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.20mL 0.44mL 0.22mL |
11.00mL 2.20mL 1.10mL |
22.00mL 4.40mL 2.20mL |
