Visomitin
产品说明书
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同义名 : | SKQ1; SKQ1 (bromide) |
| CAS号 : | 934826-68-3 | |
| 货号 : | A723646 | |
| 分子式 : | C36H42BrO2P | |
| 纯度 : | 98%+ | |
| 分子量 : | 617.6 | |
| MDL号 : | MFCD29477502 | |
| 存储条件： |
Pure form Inert atmosphere, store in freezer, under -20°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
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| 描述 | Reactive oxygen species (ROS) are a group of highly reactive oxygen-containing chemicals. Normally, the intracellular ROS level is undertight control by various antioxidants. Any disruption in the oxidation–antioxidation balance will lead to oxidative stress which is associated with a wide spectrum of human disorders. SkQ1 is a new antioxidant with the highest mitochondrion membrane penetrating ability and potent antioxidant capability. SkQ1 up-regulated production of angiogenic factors in serum and tumor of PDAC (pancreatic ductal adenocarcinoma)-bearing mice. Furthermore, an increase was observed in VEGF (vascular endothelial growth factor) concentration in serum of mice treated with SkQ1. Also, an increase in the IL-6 and IL-13 amount was found in the SkQ1 treated groups and the TGF-β amount was decreased in the pretreatment setting supporting the fact that SkQ1 can directly influence cytokine production from immune cells. This can be further illustrated by a significant decrease in the TNF-α and IFN-α production and a tendency to decrease the production of IL-6 and IL-10. Moreover, this drug at 500 nM concentration reduced heavily the proliferation of human PDAC cells[1]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
1.62mL 0.32mL 0.16mL |
8.10mL 1.62mL 0.81mL |
16.19mL 3.24mL 1.62mL |
| 参考文献 |
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