同义名 :	2-氰基-4-羟基 ;α-Cyano-4-hydroxycinnamate; CHC; α-CHCA, α-Cyano-4-hydroxycinnamic acid, CHC; NSC 173138; α-CHCA
	CAS号 :	28166-41-8
	货号 :	A722869
	分子式 :	C10H7NO3
	纯度 :	98%
	分子量 :	189.17
	MDL号 :	MFCD00004204
	存储条件：	Pure form Inert atmosphere, 2-8°C In solvent -20°C:3-6个月-80°C:12个月
	溶解度 :	-
	动物实验配方：

生物活性

描述

α-Cyano-4-hydroxycinnamic acid is a potent, non-competitive inhibitor of monocarboxylate transporters (MCTs). α-Cyano-4-hydroxycinnamic acid inhibits the mitochondrial pyruvate transporter with a Ki value of 6.3 μM. α-Cyano-4-hydroxycinnamic acid may be used as an inhibitor of the mitochondrial pyruvate transporter. Hydroxycinnamic acid can be used as a matrix to facilitate peptide ionization in MALDI-TOF mass spectrometry applications[1][2].α-Cyano-4-hydroxycinnamic acid inhibits the transport of monocarboxylates such as lactate and pyruvate[2].1 mM concentration of α-Cyano-4-hydroxycinnamic acid has a significant inhibitory effect on branching morphogenesis and reduces epithelial perimeter and area of lung explants in a dose-dependent manner[2].At a concentration of 100 μM, α-Cyano-4-hydroxycinnamic acid rapidly and almost completely inhibits O2 uptake during pyruvate oxidation in rat heart mitochondria. Inhibition was detected at inhibitor concentrations as low as 1 μM, although time was required for inhibition to occur at this concentration[1].

实验方案
	1mg	5mg	10mg
1 mM 5 mM 10 mM	5.29mL 1.06mL 0.53mL	26.43mL 5.29mL 2.64mL	52.86mL 10.57mL 5.29mL

参考文献