Nutlin-3b

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Chemical Structure| 675576-97-3 同义名 : (+)-Nutlin-3
CAS号 : 675576-97-3
货号 : A722322
分子式 : C30H30Cl2N4O4
纯度 : 99%+
分子量 : 581.49
MDL号 : MFCD11977784
存储条件：

Pure form Sealed in dry, room temperature

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 Nutlin-3b acts as an inhibitor of the p53/MDM2 interaction, with an IC50 of 13.6 μM, showcasing a binding affinity to MDM2 that is 150-fold less potent than that of Nutlin-3a[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.72mL

0.34mL

0.17mL

8.60mL

1.72mL

0.86mL

17.20mL

3.44mL

1.72mL
参考文献

[1]Vassilev LT, et al. In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science. 2004 Feb 6;303(5659):844-8.