JQ-1 (carboxylic acid)

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Chemical Structure| 202592-23-2 同义名 : -
CAS号 : 202592-23-2
货号 : A717701
分子式 : C19H17ClN4O2S
纯度 : 98%
分子量 : 400.88
MDL号 : MFCD28167916
存储条件：

Pure form Sealed in dry, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 JQ-1 carboxylic acid is known for its ability to downregulate PD-L1 expression on the surface of B16F10 cells, suggesting potential applications in cancer immunotherapy by modifying immune checkpoint interactions[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.49mL

0.50mL

0.25mL

12.47mL

2.49mL

1.25mL

24.95mL

4.99mL

2.49mL
参考文献

[1]Huang Y, et, al. Design, Synthesis, and Evaluation of Trivalent PROTACs Having a Functionalization Site with Controlled Orientation. Bioconjug Chem. 2022 Jan 19;33(1):142-151.