Sinefungin
产品说明书
 |
同义名 : | Antibiotic 32232RP; A-9145; RP 32232; Antibiotic A 9145; Adenosyl-Ornithine |
| CAS号 : | 58944-73-3 | |
| 货号 : | A713137 | |
| 分子式 : | C15H23N7O5 | |
| 纯度 : | 99%+ | |
| 分子量 : | 381.39 | |
| MDL号 : | MFCD00865623 | |
| 存储条件： |
Pure form Inert atmosphere, store in freezer, under -20°C In solvent -20°C:3-6个月-80°C:12个月 |
|
| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Sinefungin is a potent inhibitor of virion mRNA(guanine-7-)-methyltransferase, mRNA(nucleoside-2'-)-methyltransferase and viral proliferation [1].Sinefungin is an SET7/9 inhibitor that ameliorates renal fibrosis by inhibiting H3K4 methylation[2].Treatment of cells with Sinefungin at concentrations of 0.5 or 1.0 μg/mL for 60 min ameliorated TGF-β1-induced increases in α-SMA and inhibited the up-regulation of histone H3K4 monomethylation in renal epithelial cells and renal fibroblasts[2]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
2.62mL 0.52mL 0.26mL |
13.11mL 2.62mL 1.31mL |
26.22mL 5.24mL 2.62mL |
