A-1155463

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Chemical Structure| 1235034-55-5 同义名 : -
CAS号 : 1235034-55-5
货号 : A710427
分子式 : C35H32FN5O4S2
纯度 : 99%+
分子量 : 669.79
MDL号 : MFCD29924714
存储条件：

Pure form Sealed in dry, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：

2% DMSO+30% PEG 300+2% Tween 80+water 6 mg/mL

生物活性
描述 A1155463 is a highly potent and selective BCL-XL inhibitor with an EC50 value of 70 nM in Molt-4 cell.
细胞研究
细胞系 浓度 检测类型 检测时间 活性说明 数据源
NCI-H146 cells Cytotoxicity assay 48 hrs Cytotoxicity against BCL-XL-dependent human NCI-H146 cells in presence of 10% human serum incubated for 48 hrs by Cell titerGlo reagent based assay, EC50=0.065 μM 25313317
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.49mL

0.30mL

0.15mL

7.47mL

1.49mL

0.75mL

14.93mL

2.99mL

1.49mL
参考文献

[1]Zhang H, Xue J, et al. Genomic analysis and selective small molecule inhibition identifies BCL-X(L) as a critical survival factor in a subset of colorectal cancer. Mol Cancer. 2015 Jul 2;14:126.

[2]Tao ZF, Hasvold L, et al. Discovery of a Potent and Selective BCL-XL Inhibitor with in Vivo Activity. ACS Med Chem Lett. 2014 Aug 26;5(10):1088-93.