同义名 :	-
	CAS号 :	106392-48-7
	货号 :	A709920
	分子式 :	C16H20N2O2
	纯度 :	99%+
	分子量 :	272.34
	MDL号 :	MFCD31544351
	存储条件：	Pure form Sealed in dry, 2-8°C In solvent -20°C:3-6个月-80°C:12个月
	溶解度 :	-
	动物实验配方：

生物活性

描述

ST271 is a potent inhibitor of protein tyrosine kinase (PTK) with IC50s of 6.7μM, also inhibits phospholipase D activation with IC50 of 9 μM. ST271 did not inhibit Ins(1,4,5)P3 generation, but did inhibit protein tyrosine phosphorylation stimulated by fMet-Leu-Phe. ST271 does not inhibit phorbol ester-stimulated PLD, indicating that it does not inhibit PLD per se, but probably acts at a site between the receptor and the phospholipase[1]. PLD was activated in response to 0.3 U/ml thrombin, and this activation was reduced by several of the PTK inhibitor ST271. ST271 partially inhibited peptide phosphorylation in the membrane preparation and in permeabilized platelets[2].

实验方案
	1mg	5mg	10mg
1 mM 5 mM 10 mM	3.67mL 0.73mL 0.37mL	18.36mL 3.67mL 1.84mL	36.72mL 7.34mL 3.67mL

参考文献

[1]Uings IJ, Thompson NT, Randall RW, Spacey GD, Bonser RW, Hudson AT, Garland LG. Tyrosine phosphorylation is involved in receptor coupling to phospholipase D but not phospholipase C in the human neutrophil. Biochem J. 1992 Feb 1;281 ( Pt 3)(Pt 3):597-600. doi: 10.1042/bj2810597. Erratum in: Biochem J 1992 May 1;283(Pt 3):919. PMID: 1371383; PMCID: PMC1130730. [2]Martinson EA, Scheible S, Presek P. Inhibition of phospholipase D of human platelets by protein tyrosine kinase inhibitors. Cell Mol Biol (Noisy-le-grand). 1994 Jul;40(5):627-34. PMID: 7526916.