同义名 :	-
	CAS号 :	1416324-85-0
	货号 :	A707204
	分子式 :	C19H22O7
	纯度 :	97%
	分子量 :	362.37
	MDL号 :	MFCD26406409
	存储条件：	Pure form Sealed in dry, 2-8°C In solvent -20°C:3-6个月-80°C:12个月
	溶解度 :	-
	动物实验配方：

生物活性

描述

The protein complex of toll-like receptor 1 and 2 (TLR1/2) is a key regulator of cytokine responses to human cytomegalovirus, lymphocytic choriomeningitis virus, and herpes simplex virus 1. CU-CPT22 is a small-molecule inhibitor of the TLR1/2 complex with an IC50 value of 0.58 ± 0.09µM. CU-CPT22 competed with Pam3CSK4 for binding to TLR1/2 with a Ki value of 0.41±0.07µM. CU-CPT22 at a concentration of 0.5µM inhibited TLR1/2 signaling without affecting other TLRs. CU-CPT22 at 8µM inhibited ~60% of TNF-α and 95% of IL-1β in RAW 264.7 cells[2]. In Otsuka-Long-Evans-Tokushima fatty rats, treatment with Cu-CPT22 significantly reduced the kidney injury molecule-1-positive area in the kidney 12 hours after myocardial infarction. Cu-CPT22-treated rats also showed significantly decreased mRNA expressions of TLR2, TLR4, MyD88, IL-1β, and CCL2 compared with vehicle-treated controls[3].

实验方案
	1mg	5mg	10mg
1 mM 5 mM 10 mM	2.76mL 0.55mL 0.28mL	13.80mL 2.76mL 1.38mL	27.60mL 5.52mL 2.76mL

参考文献

[1]Cheng K, Wang X, et al. Discovery of small-molecule inhibitors of the TLR1/TLR2 complex. Angew Chem Int Ed Engl. 2012;51(49):12246-9. [2]Cheng K, Wang X, Zhang S, Yin H. Discovery of small-molecule inhibitors of the TLR1/TLR2 complex. Angew Chem Int Ed Engl. 2012 Dec 3;51(49):12246-9. [3]Ohno K, Kuno A, Murase H, Muratsubaki S, Miki T, Tanno M, Yano T, Ishikawa S, Yamashita T, Miura T. Diabetes increases the susceptibility to acute kidney injury after myocardial infarction through augmented activation of renal Toll-like receptors in rats. Am J Physiol Heart Circ Physiol. 2017 Dec 1;313(6):H1130-H1142.