NMS-E973

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Chemical Structure| 1253584-84-7 同义名 : -
CAS号 : 1253584-84-7
货号 : A705661
分子式 : C22H22N4O7
纯度 : 99%
分子量 : 454.43
MDL号 : MFCD28099810
存储条件：

Pure form Inert atmosphere, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 NMS-E973 is a potent and selective Hsp90 inhibitor with DC50 of < 10 nM for Hsp90 binding, no activiy against a panel of 52 diverse protein kinases.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.20mL

0.44mL

0.22mL

11.00mL

2.20mL

1.10mL

22.01mL

4.40mL

2.20mL
参考文献

[1]Fogliatto G, Gianellini L, et al. NMS-E973, a novel synthetic inhibitor of Hsp90 with activity against multiple models of drug resistance to targeted agents, including intracranial metastases. Clin Cancer Res. 2013 Jul 1;19(13):3520-32.

[2]Brasca MG, Mantegani S, et al. Discovery of NMS-E973 as novel, selective and potent inhibitor of heat shock protein 90 (Hsp90). Bioorg Med Chem. 2013 Nov 15;21(22):7047-63.