R59949
产品说明书
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同义名 : | Diacylglycerol Kinase Inhibitor II; DKGI-II |
| CAS号 : | 120166-69-0 | |
| 货号 : | A701829 | |
| 分子式 : | C28H25F2N3OS | |
| 纯度 : | 99%+ | |
| 分子量 : | 489.58 | |
| MDL号 : | MFCD00069258 | |
| 存储条件： |
Pure form Inert atmosphere,Store in freezer, under -20°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | R59949 is a pan diacylglycerol kinase (DGK) inhibitor with an IC50 value of 300 nM. R59949 strongly inhibits type I DGK α and γ activity, and moderately attenuates type II DGK θ and κ activity. R59949 activates PKC by increasing the levels of the endogenous ligand diacylglycerol[1][2][3]. .In the presence of R59949, vasopressin as well as collagen-induced release reactions and aggregation are strongly increased, independent of the formation of arachidonic acid metabolites[1].In THP-1 monocytes, R59949 attenuates CCL2-induced Ca2+ signalling at a half-maximal concentration of 8.6 μM[2].R59949 inhibits inducible nitric oxide production by reducing transplasma membrane L-arginine uptake in vascular smooth muscle cells[4]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.04mL 0.41mL 0.20mL |
10.21mL 2.04mL 1.02mL |
20.43mL 4.09mL 2.04mL |
