MK2-IN-3 hydrate
产品说明书
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同义名 : | MK2 Inhibitor III |
| CAS号 : | 1186648-22-5 | |
| 货号 : | A699021 | |
| 分子式 : | C21H18N4O2 | |
| 纯度 : | 95+% | |
| 分子量 : | 358.39 | |
| MDL号 : | MFCD28143748 | |
| 存储条件： |
Pure form Keep in dark place, sealed in dry, 2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | MK2-IN-3 hydrate is an orally active, selective, and ATP-competitive inhibitor of MAPKAP-K2 (MK-2) with an IC50 of 0.85 nM. MK2-IN-3 hydrate is effective against MK-3 (IC50=0.21 μM), MK-5 (IC50=0.081 μM), ERK2 (IC50=3.44 μM), MNK1 (IC50=5.7 μM), CDK2, JNK2, IKK2, MSK1 and MSK2, confirming its selectivity. MK2-IN-3 hydrate can inhibit the production of TNFα in U397 cells, with an IC50 of 4.4 μM[1]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.79mL 0.56mL 0.28mL |
13.95mL 2.79mL 1.40mL |
27.90mL 5.58mL 2.79mL |
