Bavisant 2HCl hydrate

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Chemical Structure| 1103522-80-0 同义名 : JNJ31001074 dihydrochloride hydrate; JNJ31001074AAC
CAS号 : 1103522-80-0
货号 : A695078
分子式 : C19H31Cl2N3O3
纯度 : 99%
分子量 : 420.37
MDL号 : MFCD26142924
存储条件：

Pure form Inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 Bavisant hydrochloride is a highly selective, orally active antagonist of the human H3 receptor with a mechanism of action, involving wakefulness and cognition, with potential as a treatment for ADHD.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.38mL

0.48mL

0.24mL

11.89mL

2.38mL

1.19mL

23.79mL

4.76mL

2.38mL
参考文献

[1]Weisler RH, Pandina GJ, et al. Randomized clinical study of a histamine H3 receptor antagonist for the treatment of adults with attention-deficit hyperactivity disorder. CNS Drugs. 2012 May 1;26(5):421-34.

[2]Hudkins RL, Raddatz R, et al. Discovery and characterization of 6-{4-[3-(R)-2-methylpyrrolidin-1-yl)propoxy] phenyl}-2H-pyridazin-3-one(CEP-26401, irdabisant): a potent, selective histamine H3 receptor inverse agonist. J Med Chem. 2011 Jul 14;54(13):4781-92.