PD184161
产品说明书
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同义名 : | - |
| CAS号 : | 212631-67-9 | |
| 货号 : | A685594 | |
| 分子式 : | C17H13BrClF2IN2O2 | |
| 纯度 : | 99%+ | |
| 分子量 : | 557.56 | |
| MDL号 : | MFCD16038897 | |
| 存储条件： |
Pure form Keep in dark place, sealed in dry, 2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | PD184161 is an orally active MEK inhibitor. It inhibits MEK activity in a time- and concentration-dependent manner with an IC50 ranging from 10 to 100 nM. PD184161 suppresses cell proliferation and induces apoptosis. It also produces antidepressant-like behaviors[1][2]. PD184161 inhibits cell proliferation and induces apoptosis in a time- and concentration-dependent manner within the concentration range of 1-20 μM, over time periods of 24, 48, or 72 hours. PD184161 (0.1 and 1.0 μM; 1 hour) inhibits the phosphorylation of ERK1,2[1]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
1.79mL 0.36mL 0.18mL |
8.97mL 1.79mL 0.90mL |
17.94mL 3.59mL 1.79mL |
| 参考文献 |
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