AGN 196996

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Chemical Structure| 958295-17-5 同义名 : -
CAS号 : 958295-17-5
货号 : A682478
分子式 : C24H20BrNO5
纯度 : 99%
分子量 : 482.32
MDL号 : MFCD28167794
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 AGN 196996 is a potent and selective RARα antagonist with Ki value of 2 nM showing little binding affinity for RARβ (Ki=1087 nM) and RARγ (Ki=8523 nM).
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.07mL

0.41mL

0.21mL

10.37mL

2.07mL

1.04mL

20.73mL

4.15mL

2.07mL
参考文献

[1]Keedwell RG, Zhao Y, et al. An antagonist of retinoic acid receptors more effectively inhibits growth of human prostate cancer cells than normal prostate epithelium. Br J Cancer. 2004 Aug 2;91(3):580-8.

[2]Hammond LA, Van Krinks CH, Durham J, et al. Antagonists of retinoic acid receptors (RARs) are potent growth inhibitors of prostate carcinoma cells. Br J Cancer. 2001 Aug 3;85(3):453-62.