同义名 :	-
	CAS号 :	19885-10-0
	货号 :	A674999
	分子式 :	C30H50O5
	纯度 :	98%
	分子量 :	490.71
	MDL号 :	MFCD09953906
	存储条件：	Pure form Sealed in dry, 2-8°C In solvent -20°C:3-6个月-80°C:12个月
	溶解度 :	-
	动物实验配方：

生物活性

描述

Alisol A is a bioactive triterpenoid isolated from the Rhizoma Alismatis. Alisol A inhibited the proliferation, migration, and invasion of NPC (nasopharyngeal carcinoma) cells by inhibiting the Hippo signaling pathway. In addition, Alisol A promoted the phosphorylation of YAP and suppressed the expression of YAP in NPC cells[3]. Alisol A remarkably decreased lipid levels, alleviated glucose metabolism disorders and insulin resistance in high-fat-diet-induced obese mice. Alisol A reduced hepatic steatosis and improved liver function in the obese mice model[4]. Alisol A can effectively inhibit the formation of arterial plaques and blocked the progression of AS in ApoE-/- mice fed with high-fat diet and significantly reduced the expression of inflammatory cytokins in aorta, including ICAM-1, IL-6, and MMP-9. Alisol A activated the AMPK/SIRT1 signaling pathway and NF-κB inhibitor IκBα in HepG2 cells[5].

实验方案
	1mg	5mg	10mg
1 mM 5 mM 10 mM	2.04mL 0.41mL 0.20mL	10.19mL 2.04mL 1.02mL	20.38mL 4.08mL 2.04mL

参考文献

[1]Ma Q, Han L, et al. Structures and biological activities of the triterpenoids and sesquiterpenoids from Alisma orientale. Phytochemistry. 2016 Nov;131:150-157. [2]Xu W, Li T, et al. Anti-proliferative activities of terpenoids isolated from Alisma orientalis and their structure-activity relationships. Anticancer Agents Med Chem. 2015;15(2):228-35. [3]Chen X, Liu H. Alisol A Inhibited the Proliferation, Migration, and Invasion of Nasopharyngeal Carcinoma Cells by Inhibiting the Hippo Signaling Pathway. Yonsei Med J. 2021 Oct;62(10):895-902 [4]Ho C, Gao Y, Zheng D, Liu Y, Shan S, Fang B, Zhao Y, Song D, Zhang Y, Li Q. Alisol A attenuates high-fat-diet-induced obesity and metabolic disorders via the AMPK/ACC/SREBP-1c pathway. J Cell Mol Med. 2019 Aug;23(8):5108-5118 [5]Wang K, Zhang B, Song D, Xi J, Hao W, Yuan J, Gao C, Cui Z, Cheng Z. Alisol A Alleviates Arterial Plaque by Activating AMPK/SIRT1 Signaling Pathway in apoE-Deficient Mice. Front Pharmacol. 2020 Nov 2;11:580073