Cabergoline

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Chemical Structure| 81409-90-7 同义名 : FCE-21336
CAS号 : 81409-90-7
货号 : A669743
分子式 : C26H37N5O2
纯度 : 98%
分子量 : 451.6
MDL号 : MFCD00867887
存储条件：

Pure form Keep in dark place, sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 Cabergoline functions as a potent agonist of D2, D3, and 5-HT2B receptors. Pre-exposure to Cabergoline inhibits hydrogen peroxide (H2O2)-induced neuronal cell death in a dose-dependent manner. In the subsequent experiments, a concentration of 10 μM of Cabergoline is employed to explore its neuroprotective effects. Immunostaining for microtubule-associated protein 2 (MAP2) demonstrates that Cabergoline significantly attenuates the neuronal loss induced by H2O2 incubation. The observation of condensed apoptotic nuclei suggests that Cabergoline mitigates apoptotic cell death subsequent to exposure to H2O2.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.21mL

0.44mL

0.22mL

11.07mL

2.21mL

1.11mL

22.14mL

4.43mL

2.21mL
参考文献

[1]Odaka H, et al. Cabergoline, dopamine D2 receptor agonist, prevents neuronal cell death under oxidative stress via reducing excitotoxicity. PLoS One. 2014 Jun 10;9(6):e99271.

[2]Jefferson F, et al. A dopamine receptor d2-type agonist attenuates the ability of stress to alter sleep in mice. Endocrinology. 2014 Nov;155(11):4411-21.