Optovin
产品说明书
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同义名 : | - |
| CAS号 : | 348575-88-2 | |
| 货号 : | A669429 | |
| 分子式 : | C15H13N3OS2 | |
| 纯度 : | 98% | |
| 分子量 : | 315.41 | |
| MDL号 : | N/A | |
| 存储条件： |
Pure form Inert atmosphere, 2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Optovin, a reversible photoactive molecule, to activate TRPA1 in individual L5 neurons of rat cortex. TRPA1 is a non-selective cation channel involved in pain sensation and neurogenic inflammation. Optical control of activity was established by applying a tightly focused femtosecond-pulsed laser to optovin-loaded neurons. Light application depolarized neurons (n = 17) with the maximal effect observed at λ = 720 nm[3]. Optovin activates human TRPA1 via structure-dependent photochemical reactions with redox-sensitive cysteine residues. In animals with severed spinal cords, optovin treatment enables control of motor activity in the paralyzed extremities by localized illumination[4]. Optogenetics is a powerful research approach that allows localized optical modulation of selected cells within an animal via the expression of genetically encoded photo-excitable ion channels. Optovin represents a novel tool for flexible, high-conductance optogenetics[5]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
3.17mL 0.63mL 0.32mL |
15.85mL 3.17mL 1.59mL |
31.70mL 6.34mL 3.17mL |
| 参考文献 |
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