SCR-1481B1 free base

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Chemical Structure| 1174161-69-3 同义名 : Metatinib free base; c-Met inhibitor 2 free base
CAS号 : 1174161-69-3
货号 : A663001
分子式 : C24H18ClF2N4O7P
纯度 : 99%+
分子量 : 578.85
MDL号 : MFCD16495773
存储条件：

Pure form Keep in dark place, sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 BMS-798433 shows greater than 50% TGI for at least one tumor doubling time with no toxicity observed during 14 days in GTL-16 human gastric tumor xenografts model.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.73mL

0.35mL

0.17mL

8.64mL

1.73mL

0.86mL

17.28mL

3.46mL

1.73mL
参考文献

[1]Onken J, Torka R, et al. Inhibiting receptor tyrosine kinase AXL with small molecule inhibitor BMS-777607 reduces glioblastoma growth, migration, and invasion in vitro and in vivo. Oncotarget. 2016 Mar 1;7(9):9876-89.