(E/Z)-Zotiraciclib

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Chemical Structure| 937270-47-8 同义名 : (E/Z)-TG02; (E/Z)-SB1317; TG02; SB1317; Zotiraciclib
CAS号 : 937270-47-8
货号 : A653995
分子式 : C23H24N4O
纯度 : 97%
分子量 : 372.46
MDL号 : MFCD22124499
存储条件：

Pure form Keep in dark place, sealed in dry, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 SB-1317 is a small molecule potent CDK2/JAK2/FLT3 inhibitor with IC50s of 13/73/56 nM respectively.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.68mL

0.54mL

0.27mL

13.42mL

2.68mL

1.34mL

26.85mL

5.37mL

2.68mL
参考文献

[1]Pasha MK, Jayaraman R, et al. Preclinical metabolism and pharmacokinetics of SB1317 (TG02), a potent CDK/JAK2/FLT3 inhibitor. Drug Metab Lett. 2012 Mar;6(1):33-42.

[2]William AD, Lee AC, et al. Discovery of kinase spectrum selective macrocycle (16E)-14-methyl-20-oxa-5,7,14,26- tetraazatetracyclo[19.3.1.1(2,6).1(8,12)] heptacosa1(25),2(26),3,5,8(27),9,11,16,21,23-decaene (SB1317/TG02), a potent inhibitor of cyclin dependent kinases (CDKs), Janus kinase 2 (JAK2), and fms-like tyrosine kinase-3 (FLT3) for the treatment of cancer. J Med Chem. 2012 Jan 12;55(1):169-96.