同义名 :	-
	CAS号 :	629664-81-9
	货号 :	A653721
	分子式 :	C25H24F2N2O3
	纯度 :	98+%
	分子量 :	438.47
	MDL号 :	MFCD13181507
	存储条件：	Pure form Sealed in dry, 2-8°C In solvent -20°C:3-6个月-80°C:12个月
	溶解度 :	-
	动物实验配方：

生物活性
描述	Turofexorate isopropyl (WAY-362450) is a potent, selective, and orally bioavailable agonist of the farnesoid X receptor (FXR) with an EC50 of 4 nM[1].

临床研究
NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT00499629	Healthy	Phase 1	Completed	-	United States, Pennsylvania ... 展开 >> Facility Philadelphia, Pennsylvania, United States, 19148 收起 <<
NCT00509756	Healthy	Phase 1	Terminated(Please see terminat... 展开 >>ion statement in the detailed description.) 收起 <<	-	Japan ... 展开 >> Tokyo, Japan, 171-0014 收起 <<

实验方案
	1mg	5mg	10mg
1 mM 5 mM 10 mM	2.28mL 0.46mL 0.23mL	11.40mL 2.28mL 1.14mL	22.81mL 4.56mL 2.28mL

参考文献

[1]Flatt B, et al. Discovery of XL335 (WAY-362450), a highly potent, selective, and orally active agonist of the farnesoid X receptor (FXR). J Med Chem. 2009 Feb 26;52(4):904-7. [2]Evans MJ, et al. A synthetic farnesoid X receptor (FXR) agonist promotes cholesterol lowering in models of dyslipidemia. Am J Physiol Gastrointest Liver Physiol. 2009 Mar;296(3):G543-52. [3]Hartman HB, et al. Activation of farnesoid X receptor prevents atherosclerotic lesion formation in LDLR-/- and apoE-/- mice. J Lipid Res. 2009 Jun;50(6):1090-100.