A 419259 3HCl

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Chemical Structure| 1435934-25-0 同义名 : RK 20449 trihydrochloride; A 419259 trihydrochloride; A-419259 trihydrochloride, A-419259 3HCl; RK-20449; A-419259 (hydrochloride)
CAS号 : 1435934-25-0
货号 : A650380
分子式 : C29H37Cl3N6O
纯度 : 99%
分子量 : 592.0
MDL号 : MFCD19690922
存储条件：

Pure form Inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 A 419259 trihydrochloride is a broad-spectrum pyrrolo-pyrimidine inhibitor, designed to enhance selectivity towards the Src family with IC50 of 9 nM, < 3 nM and < 3 nM for Src, Lck and Lyn, respectively.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.69mL

0.34mL

0.17mL

8.45mL

1.69mL

0.84mL

16.89mL

3.38mL

1.69mL
参考文献

[1]Pene-Dumitrescu T, Peterson LF, et al. An inhibitor-resistant mutant of Hck protects CML cells against the antiproliferative and apoptotic effects of the broad-spectrum Src family kinase inhibitor A-419259. Oncogene. 2008 Nov 27;27(56):7055-69.

[2]Wilson MB, Schreiner SJ, et al. Selective pyrrolo-pyrimidine inhibitors reveal a necessary role for Src family kinases in Bcr-Abl signal transduction and oncogenesis. Oncogene. 2002 Nov 21;21(53):8075-88.