同义名 :	GS 6615 hydrochloride; Eleclazine hydrochloride
	CAS号 :	1448754-43-5
	货号 :	A642597
	分子式 :	C21H17ClF3N3O3
	纯度 :	99%+
	分子量 :	451.83
	MDL号 :	MFCD30377215
	存储条件：	Pure form Sealed in dry,2-8°C In solvent -20°C:3-6个月-80°C:12个月
	溶解度 :	-
	动物实验配方：

生物活性

描述

Eleclazine (GS 6615) hydrochloride, identified as a selective inhibitor of the cardiac late sodium current and a mild inhibitor of the potassium current with IC50 values of <1 μM and approximately 14.2 μM respectively, has been shown to offer protection against autonomically induced atrial premature beats, repolarization alternans and heterogeneity, and atrial fibrillation in a porcine model, suggesting its potential use in cardiac arrhythmias research[1].[2].[3].

实验方案
	1mg	5mg	10mg
1 mM 5 mM 10 mM	2.21mL 0.44mL 0.22mL	11.07mL 2.21mL 1.11mL	22.13mL 4.43mL 2.21mL

参考文献

[1]Bacic D, et al. Eleclazine, an inhibitor of the cardiac late sodium current, is superior to flecainide in suppressing catecholamine-induced ventricular tachycardia and T-wave alternans in an intact porcine model. Heart Rhythm. 2017 Mar;14(3):448-454. [2]Rajamani S et al. The novel late Na+ current inhibitor, GS-6615 (eleclazine) and its anti-arrhythmic effects in rabbit isolated heart preparations. Br J Pharmacol. 2016 Jul 23. [3]Potet F, Egecioglu DE, Burridge PW, George AL Jr. GS-967 and Eleclazine Block Sodium Channels in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Mol Pharmacol. 2020 Nov;98(5):540-547.