FIPI

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Chemical Structure| 939055-18-2 同义名 : 5-Fluoro-2-indolyl deschlorohalopemide
CAS号 : 939055-18-2
货号 : A642372
分子式 : C23H24FN5O2
纯度 : 98%
分子量 : 421.47
MDL号 : MFCD18382115
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 FIPI is a derivative of halopemide which potently inhibits both PLD1 (IC50 = 25 nM) and PLD2 (IC50 = 20 nM) preventing PLD regulation of F-actin cytoskeleton reorganization, cell spreading, and chemotaxis.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.37mL

0.47mL

0.24mL

11.86mL

2.37mL

1.19mL

23.73mL

4.75mL

2.37mL
参考文献

[1]Su W, Yeku O, et al. 5-Fluoro-2-indolyl des-chlorohalopemide (FIPI), a phospholipase D pharmacological inhibitor that alters cell spreading and inhibits chemotaxis. Mol Pharmacol. 2009 Mar;75(3):437-46.

[2]Monovich L, Mugrage B, et al. Optimization of halopemide for phospholipase D2 inhibition. Bioorg Med Chem Lett. 2007 Apr 15;17(8):2310-1.