(3R,4S)-Tofacitinib

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Chemical Structure| 1092578-46-5 同义名 : -
CAS号 : 1092578-46-5
货号 : A629449
分子式 : C16H20N6O
纯度 : 99%
分子量 : 312.37
MDL号 : MFCD23160057
存储条件：

Pure form Keep in dark place, inert atmosphere, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 (3R,4S)-Tofacitinib is an isomer of tofacitinib, an inhibitor of JAK3 with IC50 of 1 nM, 20- to 100-fold less potent against JAK2 and JAK1.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.20mL

0.64mL

0.32mL

16.01mL

3.20mL

1.60mL

32.01mL

6.40mL

3.20mL
参考文献

[1]Changelian PS, Flanagan ME, et al, Prevention of organ allograft rejection by a specific Janus kinase 3 inhibitor. Science, 2003, 302(5646), 875-878.