TIC10
产品说明书
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同义名 : | ONC201 |
| CAS号 : | 1616632-77-9 | |
| 货号 : | A623864 | |
| 分子式 : | C24H26N4O | |
| 纯度 : | 99%+ | |
| 分子量 : | 386.49 | |
| MDL号 : | MFCD28118993 | |
| 存储条件： |
Pure form Sealed in dry, store in freezer, under -20°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | TRAIL is an endogenous protein that induces fulminant tumor-specific apoptosis through binding to death receptors DR4 or DR5 expressed in human tumor cells[2]. TIC10 is a novel small molecule inducer of the human TRAIL gene that improves efficacy-limiting properties of recombinant TRAIL. TIC10, which is the most potent inducer of cell death, exclusively activate Foxo3a through inactivation of Akt/ERK to upregulate TRAIL and its pro-apoptotic death receptor DR5[2]. In a vivo experiment, TIC10 induced a delayed and modest amount of cell death that was apparent at 72 hours post-treatment with a 1 μM dose. TIC10 can synergistically inhibit Panc-1 xenograft growth in SCID mice. TIC10 at 5-25 μM significantly decreased viability of Panc-1 cells[2]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.59mL 0.52mL 0.26mL |
12.94mL 2.59mL 1.29mL |
25.87mL 5.17mL 2.59mL |
| 参考文献 |
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