Zabadinostat
产品说明书
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同义名 : | CXD101; HDAC-IN-4; AZD 9468 |
| CAS号 : | 934828-12-3 | |
| 货号 : | A623282 | |
| 分子式 : | C24H29N5O | |
| 纯度 : | 99%+ | |
| 分子量 : | 403.52 | |
| MDL号 : | MFCD30489755 | |
| 存储条件： |
Pure form Keep in dark place, sealed in dry, 2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
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| 描述 | Histone deacetylases (HDAC) are enzymes that catalyze the removal of acetyl functional groups from the lysine residues of histones and non-histone proteins. HDAC inhibitors are a new class of anti-cancer agents that induce apoptosis and cell cycle arrest in cancer cells. CXD-101 is a class I-selective HDAC inhibitor that inhibits HDAC1, HDAC2, and HDAC3 with IC50 values of 63, 570, and 550nM, respectively, and had no activity against class II HDAC[1]. The IC50 values of CXD-101 in colon, lung, non-Hodgkin lymphoma, and myeloma cell lines ranged from 0.2 to 15μM. In murine lung (A549a) and colon (HT29) models, CXD-101 reduced tumor size at a dose of 50mg/kg, which was found to be associated with decreased HDAC enzyme activity and increased histone acetylation[2]. | ||
| 实验方案 | |||
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| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.48mL 0.50mL 0.25mL |
12.39mL 2.48mL 1.24mL |
24.78mL 4.96mL 2.48mL |
| 参考文献 |
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