BMS-582949 HCl

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Chemical Structure| 912806-16-7 同义名 : BMS-582949 hydrochloride
CAS号 : 912806-16-7
货号 : A612623
分子式 : C22H27ClN6O2
纯度 : 99%
分子量 : 442.94
MDL号 : MFCD30187517
存储条件：

Pure form Inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 BMS-582949 hydrochloride is a highly selective p38α MAPK inhibitor, inhibits p38α with IC50 of 13 nM.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.26mL

0.45mL

0.23mL

11.29mL

2.26mL

1.13mL

22.58mL

4.52mL

2.26mL
参考文献

[1]Emami H, Vucic E, et al. The effect of BMS-582949, a P38 mitogen-activated protein kinase (P38 MAPK) inhibitor on arterial inflammation: a multicenter FDG-PET trial. Atherosclerosis. 2015 Jun;240(2):490-6.

[2]Liu C, Lin J, et al. Discovery of 4-(5-(cyclopropylcarbamoyl)-2-methylphenylamino)-5-methyl-N-propylpyrrolo[1,2-f] [1,2,4] triazine-6-carboxamide (BMS-582949), a clinical p38α MAP kinase inhibitor for the treatment of inflammatory diseases. J Med Chem. 2010 Sep 23;53(18):6629-39.