同义名 :	-
	CAS号 :	464930-42-5
	货号 :	A612447
	分子式 :	C42H53ClN4O7S
	纯度 :	98%
	分子量 :	793.41
	MDL号 :	MFCD09260115
	存储条件：	Pure form Inert atmosphere, 2-8°C In solvent -20°C:3-6个月-80°C:12个月
	溶解度 :	-
	动物实验配方：

生物活性
描述	SSR240612 is a novel non-peptide antagonist of the bradykinin B1 receptor, with 500-1,000 fold selectivity for B1 over B2. It could inhibit the binding of peptide [3H]Lys0-des-Arg9-BK to bradykinin B1 receptor with Ki values of 0.48 and 0.73 nM for human fibroblast MRC5 and human embryonic kidney cells expressing recombinant human B1 receptor, respectively. SSR240612 antagonized Lys0-desAr9-BK both in vitro and in vivo. It inhibited Lys0-desAr9-BK-induced inositol monophosphate formation in MRC5 with an IC50 of 1.9 nM. Administration of SSR240612 at dose of 3 and 10 mg/kg p.o., or 0.3 and 1 mg/kg i.p., inhibited desAr9-BK-induced paw edema in mice[1]. Oral administration of SSR240612 at dose of 10mg/kg once daily for 7 days reversed low state inflammation in adipose tissue and plasma fatty acids changes associated with insulin resistance in glucose-fed rats[2].
作用机制	SSR240612 is a competitive inhibitor of bradykinin B1 receptor.[1]

实验方案
	1mg	5mg	10mg
1 mM 5 mM 10 mM	1.26mL 0.25mL 0.13mL	6.30mL 1.26mL 0.63mL	12.60mL 2.52mL 1.26mL

参考文献

[1]Gougat J, Ferrari B, et al. SSR240612 [(2R)-2-[((3R)-3-(1,3-benzodioxol-5-yl)-3-[[(6-methoxy-2-naphthyl)sulfonyl]amino]propanoyl)amino]-3-(4-[[2R,6S)-2,6-dimethylpiperidinyl]methyl]phenyl)-N-isopropyl-N-methylpropanamide hydrochloride], a new nonpeptide antagonist of the bradykinin B1 receptor: biochemical and pharmacological characterization. J Pharmacol Exp Ther. 2004 May;309(2):661-9. Epub 2004 Jan 27. [2]Dias JP, Couture R, et al. Blockade of kinin B(1) receptor reverses plasma fatty acids composition changes and body and tissue fat gain in a rat model of insulin resistance. Diabetes Obes Metab. 2012 Mar;14(3):244-53.