同义名 :	Podophyllotoxin; NSC 24818; Condyline; Wartec; Condylox; PPT; (–)-Podophyllotoxin
	CAS号 :	518-28-5
	货号 :	A608652
	分子式 :	C22H22O8
	纯度 :	98% +(synthetic)
	分子量 :	414.41
	MDL号 :	MFCD00075290
	存储条件：	Pure form Sealed in dry, 2-8°C In solvent -20°C:3-6个月-80°C:12个月
	溶解度 :	-
	动物实验配方：

生物活性

描述

Podophyllotoxin is a naturally occurring aryltetralin lignans extracted from the roots and rhizomes of Podophyllum species. It exhibited antineoplastic effect on P-388, A-549, and HT-29 cell lines with IC50 values of 0.012, 0.012, and 0.024 μM, respectively. Podophyllotoxin also showed anti-proliferative activity against NCI-H460 human non-small cell lung carcinoma cell line with IC50 value of 0.005 μg/mL[3]. The IC50 values for podophyllotoxin against the cell growth of J45.01, U-266B1, HL-60, HL-60/MX1, HL-60/MX2, CCRF-CEM, and CEM/C1 cell lines were 0.0040, 0.0064, 0.0085, 0.0078, 0.0106, 0.0064, and 0.0286 μg/mL, respectively[4]. In a mouse xenograft model inoculated with NCI-H460 cells, the combined treatment of 5 mg/kg podophyllotoxin acetate, a podophyllotoxin derivative, and infrared significantly enhanced cell death via inducing apoptosis as compared to control group[5].

实验方案
	1mg	5mg	10mg
1 mM 5 mM 10 mM	2.41mL 0.48mL 0.24mL	12.07mL 2.41mL 1.21mL	24.13mL 4.83mL 2.41mL

参考文献

[1]Wang B, Chen L, et al. Proteomic changes induced by podophyllotoxin in human cervical carcinoma HeLa cells. Am J Chin Med. 2013;41(1):163-75. [2]Guerrero E, Abad A, et al. Analgesic and anti-inflammatory activity of podophyllotoxin derivatives. Pharm Biol. 2013 May;51(5):566-72. [3]Xu H, Lv M, Tian X. A review on hemisynthesis, biosynthesis, biological activities, mode of action, and structure-activity relationship of podophyllotoxins: 2003-2007. Curr Med Chem. 2009;16(3):327-49. doi: 10.2174/092986709787002682. PMID: 19149581. [4]Och M, Och A, Cieśla Ł, Kubrak T, Pecio Ł, Stochmal A, Kocki J, Bogucka-Kocka A. Study of cytotoxic activity, podophyllotoxin, and deoxypodophyllotoxin content in selected Juniperus species cultivated in Poland. Pharm Biol. 2015 Jun;53(6):831-7. doi: 10.3109/13880209.2014.943246. Epub 2015 Feb 27. PMID: 25720974. [5]Choi JY, Cho HJ, Hwang SG, Kim WJ, Kim JI, Um HD, Park JK. Podophyllotoxin acetate enhances γ-ionizing radiation-induced apoptotic cell death by stimulating the ROS/p38/caspase pathway. Biomed Pharmacother. 2015 Mar;70:111-8. doi: 10.1016/j.biopha.2014.12.038. Epub 2015 Jan 12. PMID: 25776488.