2,4-Diamino-6-hydroxypyrimidine
产品说明书
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同义名 : | DAHP |
| CAS号 : | 56-06-4 | |
| 货号 : | A608015 | |
| 分子式 : | C4H6N4O | |
| 纯度 : | 97% | |
| 分子量 : | 126.12 | |
| MDL号 : | MFCD08528919 | |
| 存储条件： |
Pure form Keep in dark place, inert atmosphere, room temperature In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | 2,4-Diamino-6-hydroxypyrimidine specifically inhibits GTP cyclohydrolase I, which is crucial in the initial step of pterin synthesis. It impedes the formation of Tetrahydrobiopterin (BH4) and consequently reduces the production of nitric oxide (NO)[1][2]. 2,4-Diamino-6-hydroxypyrimidine, also known as DAHP, demonstrates a dose-related decrease in nitric oxide (NO) levels in chicken peritoneal macrophages (PECs) and the avian MC29 virus-transformed macrophage cell line, HD11[1]. Treatment with 2,4-Diamino-6-hydroxypyrimidine (DAHP; at a concentration of 5 mM for 24 hours) notably decreases levels of both BH4 and VCAM-1 over time in HUVEC cells. The synthesis of VCAM-1 and GTPCH proteins is reduced by 2,4-Diamino-6-hydroxypyrimidine, which is partially due to the suppression of NF-κB within the nucleus of HUVEC[2]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
7.93mL 1.59mL 0.79mL |
39.64mL 7.93mL 3.96mL |
79.29mL 15.86mL 7.93mL |
