NMDA-IN-1

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Chemical Structure| 700878-19-9 同义名 : -
CAS号 : 700878-19-9
货号 : A607428
分子式 : C20H23ClFN3O
纯度 : 98+%
分子量 : 375.87
MDL号 : -
存储条件：

Pure form Inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 NMDA-IN-1 is a potent and NR2B-selective NMDA antagonist with Ki of 0.85 nM. Its NR2B Ca2+ influx IC50 is 9.7 nM without activities on NR2A, NR2C, NR2D, hERG-channel and α1-adrenergic receptor.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.66mL

0.53mL

0.27mL

13.30mL

2.66mL

1.33mL

26.60mL

5.32mL

2.66mL
参考文献

[1]McCauley JA, Theberge CR, et al. NR2B-selective N-methyl-D-aspartate antagonists: synthesis and evaluation of 5-substituted benzimidazoles. J Med Chem. 2004 Apr 8;47(8):2089-96.