MP-A08
产品说明书
 |
同义名 : | NSC 122314 |
| CAS号 : | 219832-49-2 | |
| 货号 : | A604393 | |
| 分子式 : | C27H25N3O4S2 | |
| 纯度 : | 98%+ | |
| 分子量 : | 519.64 | |
| MDL号 : | MFCD01053753 | |
| 存储条件： |
Pure form Sealed in dry, 2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | MP-A08 functions by impeding pro-proliferative signaling pathways and triggers mitochondrial-associated apoptosis specifically through sphingosine kinase (SK) dependency. It effectively reduces the growth of human lung adenocarcinoma tumors in a mouse xenograft model by both inducing tumor cell apoptosis and inhibiting tumor angiogenesis. MP-A08's inhibition of SphK2 leads to a diminished endothelial cell (EC) barrier integrity in vitro across various cell types[2]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
1.92mL 0.38mL 0.19mL |
9.62mL 1.92mL 0.96mL |
19.24mL 3.85mL 1.92mL |
| 参考文献 |
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