E 64c

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Chemical Structure| 76684-89-4 同义名 : Loxistatin acid; NSC 694279; EP 475
CAS号 : 76684-89-4
货号 : A602643
分子式 : C15H26N2O5
纯度 : 95%
分子量 : 314.38
MDL号 : MFCD00132882
存储条件：

Pure form Sealed in dry, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
靶点

  • Cysteine Protease
描述 E-64c is a derivative of a naturally occurring epoxide that inhibits cysteine proteases, particularly effective against papain. This inhibition is characterized by the hydrogen bonding and hydrophobic interactions between the ligands and the conserved residues within the catalytic binding site[1]. E-64c has been identified as a primary structure for the creation of irreversible inhibitors targeting cathepsin C[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.18mL

0.64mL

0.32mL

15.90mL

3.18mL

1.59mL

31.81mL

6.36mL

3.18mL
参考文献

[1]McGowan EB, Becker E, et al. Inhibition of calpain in intact platelets by the thiol protease inhibitor E-64d. Biochem Biophys Res Commun. 1989 Jan 31;158(2):432-5.

[2]Noda T, Isogai K, et al. Effects of cathepsin B, H, and D in pectoral muscle of dystrophic chickens (line 413) of in vivo administration of E-64-c (N-[N-(L-3-transcarboxyoxirane-2-carbonyl)-L-leucyl] -3-methyl-butylamine). J Biochem. 1981 Sep;90(3):893-6.