Loxoribine
产品说明书
 |
同义名 : | RWJ 21757; 7-Allyl-8-oxoguanosine; Loxoribinum; Loxoribina |
| CAS号 : | 121288-39-9 | |
| 货号 : | A602237 | |
| 分子式 : | C13H17N5O6 | |
| 纯度 : | 99%+ | |
| 分子量 : | 339.3 | |
| MDL号 : | MFCD00867591 | |
| 存储条件： |
Pure form Keep in dark place, inert atmosphere, 2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
|
| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Loxoribine is a guanosine analogue with antiviral and antitumour activity. Loxoribine is an orally bioactive and selective TLR7 agonist[1][2][3].Loxoribine induces DC maturation in human monocyte-derived dendritic cells and stimulates their Th-1 and Th-17 polarising capacity[2].At a concentration of 250 μM for 48 hours, Loxoribine stimulates the maturation of MoDCs, as evidenced by the upregulation of CD80, CD83, CD40, CD54 and CCR7[2].Loxoribine selectively activates cells of the innate immune system through the TLR7/MyD88-dependent signalling pathway[1]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
2.95mL 0.59mL 0.29mL |
14.74mL 2.95mL 1.47mL |
29.47mL 5.89mL 2.95mL |
