TBHQ
产品说明书
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同义名 : | 叔丁基对苯二酚（TBHQ） ;tert-Butylhydroquinone |
| CAS号 : | 1948-33-0 | |
| 货号 : | A598680 | |
| 分子式 : | C10H14O2 | |
| 纯度 : | 99% | |
| 分子量 : | 166.21 | |
| MDL号 : | MFCD00002344 | |
| 存储条件： |
Pure form Inert atmosphere, room temperature In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | TBHQ, known as tert-Butylhydroquinone, is commonly employed as an Nrf2 activator and offers protection from cardiotoxicity caused by Doxorubicin (DOX) by stimulating Nrf2[1]. Additionally, TBHQ serves as an ERK activator and counteracts the inhibitory effect on cell proliferation in melanoma induced by Dehydrocorydaline (DHC)[2]. TBHQ, when used alone at concentrations ranging from 0 to 100 μM over 48 hours, does not compromise the viability of H9c2 cells. However, a 24-hour pre-treatment with TBHQ at varying concentrations significantly bolsters the viability of H9c2 cells, which otherwise diminishes in response to ethanol in a dose-responsive manner. Furthermore, TBHQ treatment notably improves the survival of H9c2 cardiomyocytes challenged with ethanol. Additionally, a brief 15-minute exposure to 5 μM TBHQ substantially curtails the number of apoptotic cells in H9c2 cells subjected to ethanol. Moreover, pre-treating H9c2 cells with 5 μM TBHQ significantly hampers the ethanol-triggered upsurge in caspase-3 and Bax levels, while concurrently elevating Bcl-2 expression[3]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
6.02mL 1.20mL 0.60mL |
30.08mL 6.02mL 3.01mL |
60.16mL 12.03mL 6.02mL |
| 参考文献 |
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