同义名 :	刺五加甙E ;Syringin E
	CAS号 :	39432-56-9
	货号 :	A593928
	分子式 :	C34H46O18
	纯度 :	99%+
	分子量 :	742.72
	MDL号 :	MFCD20036283
	存储条件：	Pure form Sealed in dry, 2-8°C In solvent -20°C:3-6个月-80°C:12个月
	溶解度 :	-
	动物实验配方：

生物活性

描述

Eleutheroside E (EE), a principal component of Eleutherococcus senticosus (ES), has anti-inflammatory and protective effects in ischemia heart. EE increased the insulin-provoked glucose uptake in C2C12 myotubes. Moreover, EE improved TNF- α -induced suppression of glucose uptake in 3T3-L1 adipocytes. EE mediates the hyperglycemic effects of ES by regulating insulin signaling and glucose utilization[3]. The IC50 values for EB and EE were calculated to be 193.20 μM and 188.36 μM for CYP2E1, 595.66 μM and 261.82 μM for CYP2C9, respectively[4]. EE administration attenuated the cardiomyocyte apoptosis induced by hypoxia-reoxygenation (H/R) injury. Further, pre-treatment with EE dramatically inhibited mitochondrial oxidative stress, IκBα phosphorylation and nuclear factor kappa B (NF-κB) subunit p65 translocation into nuclei. EE might suppress the MAPK signaling pathway to inhibit the H/R-induced NF-κB activation. EE may be a potential drug for myocardial I/R injury by reducing oxidative stress, NF-κB activation, and metabolic reprogramming[5].

实验方案
	1mg	5mg	10mg
1 mM 5 mM 10 mM	1.35mL 0.27mL 0.13mL	6.73mL 1.35mL 0.67mL	13.46mL 2.69mL 1.35mL

参考文献

[1]Yang X, Wang Y, et al. High glucose induces rat mesangial cells proliferation and MCP-1 expression via ROS-mediated activation of NF-κB pathway, which is inhibited by eleutheroside E. J Recept Signal Transduct Res. 2016;36(2):152-7. [2]Ahn J, Um MY, et al. Eleutheroside E, An Active Component of Eleutherococcus senticosus, Ameliorates Insulin Resistance in Type 2 Diabetic db/db Mice. Evid Based Complement Alternat Med. 2013;2013:934183. [3]Ahn J, Um MY, Lee H, Jung CH, Heo SH, Ha TY. Eleutheroside E, An Active Component of Eleutherococcus senticosus, Ameliorates Insulin Resistance in Type 2 Diabetic db/db Mice. Evid Based Complement Alternat Med. 2013;2013:934183 [4]Guo S, Liu Y, Lin Z, Tai S, Yin S, Liu G. Effects of eleutheroside B and eleutheroside E on activity of cytochrome P450 in rat liver microsomes. BMC Complement Altern Med. 2014 Jan 2;14:1 [5]Wang S, Yang X. Eleutheroside E decreases oxidative stress and NF-κB activation and reprograms the metabolic response against hypoxia-reoxygenation injury in H9c2 cells. Int Immunopharmacol. 2020 Jul;84:106513