BMS 299897

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Chemical Structure| 290315-45-6 同义名 : -
CAS号 : 290315-45-6
货号 : A591719
分子式 : C24H21ClF3NO4S
纯度 : 99+%
分子量 : 511.94
MDL号 : MFCD12963627
存储条件：

Pure form Sealed in dry, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 BMS 299897 is an orally active, potent γ-secretase inhibitor (IC50 = 12 nM).
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.95mL

0.39mL

0.20mL

9.77mL

1.95mL

0.98mL

19.53mL

3.91mL

1.95mL
参考文献

[1]Weissmiller AM, Natera-Naranjo O, et al. A γ-secretase inhibitor, but not a γ-secretase modulator, induced defects in BDNF axonal trafficking and signaling: evidence for a role for APP. PLoS One. 2015 Feb 24;10(2):e0118379.

[2]Meunier J, Villard V, et al. The γ-secretase inhibitor 2-[(1R)-1-[(4-chlorophenyl)sulfonyl] (2,5-difluorophenyl) amino] ethyl-5-fluorobenzenebutanoic acid (BMS-299897) alleviates Aβ1-42 seeding and short-term memory deficits in the Aβ25-35 mouse model of Alzheimer's disease. Eur J Pharmacol. 2013 Jan 5;698(1-3):193-9.