LH846

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Chemical Structure| 639052-78-1 同义名 : -
CAS号 : 639052-78-1
货号 : A591543
分子式 : C16H13ClN2OS
纯度 : 99%+
分子量 : 316.81
MDL号 : MFCD03786038
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 LH846 effectively targets CKIδ with an IC50 of 290 nM and shows lesser inhibition towards CKIα and CKIε, with IC50 values of 2.5 μM and 1.3 μM, respectively, while it does not impact CK2. At concentrations of 3 or 10 μM, LH846 blocks CKIδ-mediated phosphorylation of PER1 in HEK293T cells[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.16mL

0.63mL

0.32mL

15.78mL

3.16mL

1.58mL

31.56mL

6.31mL

3.16mL
参考文献

[1]Lee JW, et al. A small molecule modulates circadian rhythms through phosphorylation of the period protein. Angew Chem Int Ed Engl. 2011 Nov 4;50(45):10608-11.